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Updated: May 9, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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[Optical coherence tomography angiography in the diagnosis of multiple sclerosis]

A Zh Fursova1,2, M Yu Zubkova1,2, M A Vasilyeva1,2

  • 1Novosibirsk State Regional Hospital, Novosibirsk, Russia.

Vestnik Oftalmologii
|May 14, 2024
PubMed
Abstract

Insights

Retinal microcirculation changes, including decreased vessel and perfusion density, worsen with multiple sclerosis (MS) duration and progression. Optical coherence tomography angiography (OCTA) detects these subclinical vascular changes in MS patients.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Context:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Retinal microcirculation alterations are increasingly recognized in MS.
  • Understanding these changes is crucial for disease management.

Purpose:

  • To analyze changes in retinal microcirculation in MS patients.
  • To correlate these changes with disease course and duration.
  • To evaluate the role of optical coherence tomography angiography (OCTA) in MS.

Summary:

  • A study examined 159 MS patients, categorized by disease course (relapsing-remitting MS and secondary progressive MS) and duration.
  • Optical coherence tomography angiography (OCTA) revealed decreased vessel density (wiVD) and perfusion density (wiPD) in macular and peripapillary regions.
  • These microcirculatory deficits progressed with disease duration and severity, being most pronounced in SPMS, especially with optic neuritis.

Impact:

  • OCTA can detect subclinical vascular changes in the retina.
  • This method offers a reliable approach for early MS diagnosis.
  • OCTA aids in monitoring MS progression and treatment efficacy.
Keywords:
expanded disability status scalemultiple sclerosisoptic neuritisoptical coherence tomography angiographyretinal microcirculation

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