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Updated: Jun 26, 2025

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
Published on: August 15, 2019
Project Optimus Elicits the "Holistic" Benefits of PK/PD Modeling of Immunotherapy
Mathangi Gopalakrishnan1, Rodabe N Amaria2
1Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland.
Abstract:
Leveraging a heterogeneous dataset, a recent article demonstrated the application of pharmacometric modeling to inform the dosing of nivolumab-relatlimab fixed-dose combination in special populations, including adolescents lacking clinical data. The use of model-informed approaches during clinical drug development can be cost-effective, which ensures fast access to drugs and enhances patient outcomes. See related article by Zhao et al., p. 3050.

