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Relationship between gastrointestinal symptoms and COVID-19 infection in the pediatric population: a scoping review

Denise Desconsi1, Juliane Pagliari Araujo1, Marcela Demitto Furtado2

  • 1Universidade Estadual de Londrina, Londrina, PR, Brazil.

Revista Da Escola De Enfermagem Da U S P
|May 14, 2024
PubMed

Insights

Gastrointestinal symptoms in children with COVID-19 are linked to the ACE2 receptor, gut-brain axis, and Multisystem Inflammatory Syndrome in children. Identifying these symptoms aids clinical management.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Gastrointestinal (GI) symptoms are increasingly recognized in pediatric COVID-19 cases.
  • The underlying mechanisms linking SARS-CoV-2 infection to GI manifestations in children require elucidation.

Purpose of the Study:

  • To systematically map existing literature on the relationship between GI symptoms and COVID-19 in pediatric populations.
  • To synthesize current evidence regarding the pathogenesis of GI symptoms in children with COVID-19.

Main Methods:

  • A comprehensive scoping review was conducted following Joanna Briggs Institute and PRISMA-ScR guidelines.
  • Searches were performed across multiple databases (Embase, PubMed, Scopus, etc.) between July and August 2023.
  • Inclusion criteria encompassed original studies of any language, available in full text.

Main Results:

  • Ten studies were included, highlighting three key premises.
  • The angiotensin-converting enzyme 2 (ACE2) receptor, crucial for viral entry, is present in the pediatric gastrointestinal tract.
  • GI symptoms are associated with stress and infection via the gut-brain axis, and can be a feature of Multisystem Inflammatory Syndrome in children (MIS-C).

Conclusions:

  • The review identified three core assumptions explaining the origin of GI symptoms in pediatric COVID-19.
  • Recognizing these GI symptoms is vital for effective clinical assessment, management, and treatment strategies in affected children.
Abstract

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