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Impaired sensitivity to thyroid hormones is associated with different grades of hypertension: A multicenter
Lu Yu1, Guangwei Pan1, Zhu Li2
1Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China.
Insights
Reduced central thyroid hormone sensitivity and increased peripheral sensitivity are linked to higher hypertension risk in coronary heart disease patients. These findings offer new insights into hypertension assessment for CHD individuals.
Area of Science:
- Endocrinology
- Cardiology
- Hypertension Research
Background:
- Thyroid function is increasingly linked to hypertension.
- Limited research exists on thyroid hormone sensitivity and hypertension grades in coronary heart disease (CHD) patients.
- Understanding this relationship is crucial for assessing hypertension in CHD.
Purpose of the Study:
- To investigate the complex interaction between the thyroid system and blood pressure in CHD patients.
- To explore the association between central and peripheral thyroid hormone sensitivity and different hypertension grades.
- To provide novel insights for hypertension assessment in the CHD population.
Main Methods:
- Calculated parameters for central and peripheral thyroid hormone sensitivity.
- Utilized logistic regression analysis to assess associations in 34,310 participants.
- Performed stratified analysis based on age, sex, blood glucose, smoking, and drinking status.
Main Results:
- Hypertension was diagnosed in 57.16% of participants.
- Decreased central thyroid hormone sensitivity (TSHI, TT4RI, TFQI, PTFQI) was negatively associated with hypertension risk (P < 0.001).
- Increased peripheral thyroid hormone sensitivity (FT3/FT4 ratio) was positively associated with hypertension risk (P < 0.001).
Conclusions:
- Reduced central thyroid hormone sensitivity is associated with increased hypertension risk in CHD patients.
- Increased peripheral thyroid hormone sensitivity is linked to a higher risk of hypertension in this cohort.
- These findings highlight the importance of evaluating thyroid hormone sensitivity in hypertension management for CHD patients.
Background And Aim:
Accumulating evidence suggests a potential link between thyroid function with hypertension. However, the research results are limited, and there is no research to explore the relationship between central and peripheral thyroid hormones (THs) sensitivity and different grades of hypertension in patients with coronary heart disease (CHD). This study aims to prove the complex interaction between thyroid system and blood pressure, and provides new ideas for the assessment of hypertension in patients with CHD.
Methods And Results:
Calculate parameters representing central and peripheral sensitivity to THs. Logistic regression analysis was used to analyze the relationship between central and peripheral THs sensitivity of CHD patients and different grades of hypertension, especially in different ages, sexes, blood glucose levels, smoking, and drinking statuses. Among the 34,310 participants, 19,610 (57.16 %) were diagnosed with hypertension. The risk of hypertension and TSHI (OR: 0.88; 95 % CI: 0.87-0.90; P < 0.001), TT4RI (OR: 0.998; 95 % CI: 0.998-0.999; P < 0.001), TFQI (OR: 0.63; 95 % CI: 0.60-0.67; P < 0.001), PTFQI (OR: 0.63; 95 % CI: 0.59-0.67; P < 0.001) was negatively associated. The risk of hypertension was positively associated with FT3/FT4 (OR: 1.20; 95 % CI: 1.17-1.22; P < 0.001). After stratified analysis, these associations remained significant at different ages, sexes, blood glucose levels, grades of hypertension, smoking, and drinking statuses (P < 0.001).
Conclusions:
This study shows that the decrease in central THs sensitivity index and the increase in peripheral THs sensitivity index are associated with a higher risk of hypertension in CHD patients.
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