Impaired sensitivity to thyroid hormones is associated with different grades of hypertension: A multicenter...

Area of Science:

• Endocrinology
• Cardiology
• Hypertension Research

Background:

• Thyroid function is increasingly linked to hypertension.
• Limited research exists on thyroid hormone sensitivity and hypertension grades in coronary heart disease (CHD) patients.
• Understanding this relationship is crucial for assessing hypertension in CHD.

Purpose of the Study:

• To investigate the complex interaction between the thyroid system and blood pressure in CHD patients.
• To explore the association between central and peripheral thyroid hormone sensitivity and different hypertension grades.
• To provide novel insights for hypertension assessment in the CHD population.

Main Methods:

• Calculated parameters for central and peripheral thyroid hormone sensitivity.
• Utilized logistic regression analysis to assess associations in 34,310 participants.
• Performed stratified analysis based on age, sex, blood glucose, smoking, and drinking status.

Main Results:

• Hypertension was diagnosed in 57.16% of participants.
• Decreased central thyroid hormone sensitivity (TSHI, TT4RI, TFQI, PTFQI) was negatively associated with hypertension risk (P < 0.001).
• Increased peripheral thyroid hormone sensitivity (FT3/FT4 ratio) was positively associated with hypertension risk (P < 0.001).

Conclusions:

• Reduced central thyroid hormone sensitivity is associated with increased hypertension risk in CHD patients.
• Increased peripheral thyroid hormone sensitivity is linked to a higher risk of hypertension in this cohort.
• These findings highlight the importance of evaluating thyroid hormone sensitivity in hypertension management for CHD patients.