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Prognostic nomogram in middle-aged and elderly patients with chordoma: A SEER-based study
Chenxi Ouyang1, Yu Sun2, Yong Li2
1Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, PR China.
Journal of Orthopaedic Surgery (Hong Kong)
|May 14, 2024
Summary
This study developed a nomogram to predict chordoma prognosis in patients aged 40 and older. The tool effectively assesses survival rates, aiding clinical decisions for personalized chordoma treatment.
Area of Science:
- Oncology
- Biostatistics
Background:
- Chordoma is a slow-growing but aggressive bone tumor.
- Prognosis differs significantly between young and older chordoma patients.
Purpose of the Study:
- To develop a predictive nomogram for individualized prognosis in middle-aged and elderly chordoma patients (age ≥ 40).
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1983-2015) with 658 chordoma patients.
- Employed univariate and multivariate Cox proportional hazards models to identify prognostic factors.
- Constructed and validated a nomogram for 3- and 5-year overall survival (OS) prediction.
Main Results:
- Identified age, tumor size, histology, primary site, surgery, and disease extent as independent prognostic factors.
- The nomogram demonstrated satisfactory predictive ability, validated by calibration curves and C-index.
- Training cohort (462 patients) and validation cohort (196 patients) were used.
Conclusions:
- The nomogram serves as an effective prognostic tool for middle-aged and elderly chordoma patients.
- Aids clinicians in medical decision-making for more accurate and reasonable treatment planning.
