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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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  • 1The Formulary.

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Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs for Pharmacy & Therapeutics Committees, including new drug reviews and drug utilization evaluations. This service aids in informed medication management and formulary decisions.

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Area of Science:

  • Pharmaceutical Sciences
  • Clinical Pharmacy
  • Health Services Research

Background:

  • Pharmacy & Therapeutics (P&T) Committees require timely and comprehensive drug information.
  • New drug approvals and late-stage clinical trials necessitate ongoing evaluation of medication use.
  • Effective drug utilization evaluation (DUE) and medication use evaluation (MUE) are critical for patient safety and cost-effectiveness.

Purpose of the Study:

  • To describe the features and content of The Formulary Monograph Service.
  • To highlight the utility of the service for healthcare professionals involved in formulary management and medication use.
  • To inform potential subscribers about the scope of information provided, including drug monographs, summary monographs, and DUE/MUEs.

Main Methods:

  • The service delivers 5-6 detailed monographs on new or late-phase trial drugs monthly.
  • One-page summary monographs are provided for pharmacy and nursing in-services.
  • Comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE) studies are included monthly.
  • A monthly drug class review is also a feature of the service.

Main Results:

  • Subscribers receive print and online access to monographs.
  • Monographs can be customized to specific facility needs.
  • January 2016 topics included idarucizumab, patiromer, coagulation factor VIII/antihemophilic factor (recombinant), cariprazine, and trifluridine and tipiracil.
  • A Safety MUE focused on idarucizumab was provided.

Conclusions:

  • The Formulary Monograph Service offers a valuable, ongoing resource for P&T Committees and healthcare professionals.
  • The service supports evidence-based formulary management and safe medication practices.
  • Subscription provides access to detailed drug information, utilization evaluations, and drug class reviews.