Related Experiment Video
Updated: Jun 26, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.9K
Cardiovascular Considerations and Implications for Treatment in Psoriasis: An Updated Review
Hitaishi Mehta1, Tarun Narang1, Sunil Dogra1
1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Vascular Health and Risk Management
|May 15, 2024
Summary
Psoriasis is linked to cardiovascular disease (CVD) through shared genetic and immune pathways. Certain treatments may reduce CVD risk, but more research is needed for comprehensive management.
Area of Science:
- Dermatology and Cardiology
- Immunology and Genetics
Background:
- Psoriasis is a chronic inflammatory skin disease with significant links to cardiovascular diseases (CVD).
- The interplay involves genetic factors, immune responses, and adipose tissue dysfunction, extending beyond traditional CVD risk factors.
Purpose of the Study:
- To review the complex relationship between psoriasis and the cardiovascular system.
- To explore genetic links, immune pathways, and treatment implications for cardiovascular risk in psoriasis patients.
Main Methods:
- Comprehensive literature review of studies on psoriasis and cardiovascular comorbidities.
- Analysis of genetic polymorphisms (e.g., IL-23, TNF-α), immune pathways, and treatment effects on cardiovascular outcomes.
Main Results:
- Psoriasis-specific genetic factors (IL-23, TNF-α) are associated with CVD.
- TNF inhibitors (TNFi) and methotrexate may reduce cardiovascular risk; IL-12/23 inhibitors' role is uncertain.
- IL-17 and IL-23 inhibitors show emerging safety and efficacy in patients with CVD.
Conclusions:
- Understanding the psoriasis-CVD link requires a multidisciplinary approach involving dermatology, rheumatology, and cardiology.
- Further research is needed on screening guidelines, disease phenotypes, and treatment hierarchies for cardiovascular risk management in psoriasis.
More Related Videos
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
01:29Cardiovascular System Abnormal Findings I: Inspection and Palpation
381
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Abnormal findings observed during an inspection
381
01:29Assessment of the Cardiovascular System II: Inspection
227
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
227
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
2.8K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.8K
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
167
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
167
01:27Assessment of the Cardiovascular System III: Palpation
318
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
318