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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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SEOM-GEM clinical guidelines for cutaneous melanoma (2023)
Iván Márquez-Rodas1, Eva Muñoz Couselo2, Juan F Rodríguez Moreno3
1Hospital General Universitario Gregorio Marañón, Madrid, Spain. ivanpantic@hotmail.com.
Summary
Rising cutaneous melanoma requires early diagnosis. New targeted and immunotherapy treatments improve survival for advanced melanoma patients, reducing relapse risks.
Area of Science:
- Oncology
- Dermatology
- Medical Guidelines
Background:
- Cutaneous melanoma incidence is increasing globally.
- Early diagnosis and treatment are critical for improving patient survival rates.
- Advanced melanoma presents significant treatment challenges.
Purpose of the Study:
- To provide updated clinical guidelines for managing cutaneous melanoma.
- To outline evidence-based strategies for diagnosis, staging, and risk stratification.
- To detail therapeutic options for locoregional and advanced melanoma.
Main Methods:
- Comprehensive review of the latest scientific evidence.
- Development of guidelines by experts from the Spanish Society of Medical Oncology (SEOM) and the Spanish Multidisciplinary Melanoma Group (GEM).
- Inclusion of diagnostic (clinical, pathological, molecular), staging, and therapeutic aspects.
Main Results:
- Adjuvant and neoadjuvant targeted therapies (BRAF/MEK inhibitors) and immunotherapies (anti-PD-1) reduce relapse in resectable advanced melanoma.
- These therapies significantly increase overall survival for unresectable advanced melanoma.
- Guidelines cover diagnosis, staging, risk stratification, adjuvant/advanced therapy, and follow-up.
Conclusions:
- Updated guidelines offer comprehensive management strategies for cutaneous melanoma.
- Clinicians are provided with decision-making support for optimal patient care.
- Focus on integrating novel therapies for improved melanoma patient outcomes.
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