Geroscience: just another name or is there more to it?
1CNRS, ImmunoConcEpT, UMR 5164, University of Bordeaux, Bordeaux, France. sokholm@immuconcept.org.
Biogerontology
|May 15, 2024
Summary
Geroscience aims to target aging for better healthspan. While promising, its readiness for human therapies remains debated, despite advances in biogerontology.
Area of Science:
- Gerontology
- Biogerontology
- Translational Research
Background:
- The term 'geroscience' is increasingly used in aging research.
- Some biogerontologists express caution regarding its widespread adoption.
- This paper examines the origin and evolution of geroscience.
Purpose of the Study:
- To define geroscience and its theoretical underpinnings.
- To explore its relationship with anti-aging medicine and biogerontology.
- To assess the current readiness of geroscience for clinical application.
Main Methods:
- Historical overview of geroscience.
- Conceptual analysis of geroscience principles.
- Comparison with biogerontology and anti-aging movements.
Main Results:
- Geroscience proposes targeting aging processes to improve human healthspan.
- Aging is recognized as malleable in model organisms, supporting translational research.
- The field has rebranded older concepts, but claims of imminent human therapies are debatable.
Conclusions:
- Geroscience represents a rebranding of established aging research, not a radical departure.
- While progress in biogerontology is significant, claims of immediate human anti-aging therapies require scrutiny.
- The field's trajectory emphasizes translational and clinical research based on aging malleability.
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