Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

666
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
666
Atomic Force Microscopy01:08

Atomic Force Microscopy

3.4K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Landau-Zener Transition Enhanced Quantum Sensing in Spin Defects of Hexagonal Boron Nitride.

ACS nano·2026
Same author

In-plane anomalous Hall effect in a low-dimensional system.

Nature materials·2026
Same author

Probing boron vacancy defects in hBN via single spin relaxometry.

Nature communications·2026
Same author

Extreme longitudinal thermal conductivity and non-diffusive heat transport in isotopic hBN.

Nature communications·2026
Same author

Cavity-altered superconductivity.

Nature·2026
Same author

Ultrabroadband Spacetime Nanoscopy of Terahertz Polaritons in a van der Waals Cavity.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Bridging nanotechnology and mechanobiology.

Nature nanotechnology·2026
Same journal

Coherent 2D/3D van der Waals epitaxy enables single-crystal perovskite heterostructures.

Nature nanotechnology·2026
Same journal

Coherent 2D-3D van der Waals perovskite epitaxial heterostructures.

Nature nanotechnology·2026
Same journal

Ultrafast, reconfigurable all-optical beam steering and spatial light modulation.

Nature nanotechnology·2026
Same journal

A high-energy hydrogen radical initiates efficient electrosynthesis of urea from CO<sub>2</sub> and N<sub>2</sub>.

Nature nanotechnology·2026
Same journal

Machine-intelligent multimodal algebot for intracavitary chemotherapy.

Nature nanotechnology·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

831

Atomic-force-microscopy-based time-domain two-dimensional infrared nanospectroscopy.

Qing Xie1, Yu Zhang2, Eli Janzen3

  • 1Department of Chemistry, Lehigh University, Bethlehem, PA, US.

Nature Nanotechnology
|May 15, 2024
PubMed
Summary
This summary is machine-generated.

We developed AFM-2DIR nanospectroscopy, combining atomic force microscopy (AFM) spatial precision with 2D IR spectroscopy for molecular insights. This technique probes vibrational energy transfer in nanomaterials with nanoscale resolution.

More Related Videos

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
08:51

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

3.9K
High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
11:05

High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology

Published on: January 21, 2015

33.2K

Related Experiment Videos

Last Updated: Jun 26, 2025

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

831
Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
08:51

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

3.9K
High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
11:05

High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology

Published on: January 21, 2015

33.2K

Area of Science:

  • Spectroscopy
  • Nanotechnology
  • Materials Science

Background:

  • Infrared (IR) spectroscopy advances spatial resolution and spectroscopic information.
  • Atomic force microscopy (AFM) offers sub-10 nm spatial resolution, overcoming diffraction limits.
  • 2D IR spectroscopy provides insights into molecular structures, coupling, and energy transfer.

Purpose of the Study:

  • To integrate AFM's spatial precision with 2D IR spectroscopy's analytical power.
  • To develop a novel nanospectroscopy technique for advanced material analysis.
  • To investigate vibrational dynamics at the nanoscale.

Main Methods:

  • Developed AFM-2DIR nanospectroscopy by combining AFM and 2D IR spectroscopy.
  • Mechanically detected photothermal responses to tip-enhanced femtosecond IR pulses.
  • Utilized Fourier Transforms (FFTs) to extract spatially resolved spectroscopic data.

Main Results:

  • Elucidated vibrational anharmonicity in a carbonyl mode.
  • Probed hyperbolic phonon polaritons in h10BN using tip-enhanced near-field photons.
  • Observed energy transfer between phonon polaritons and phonons, and among polariton modes.

Conclusions:

  • AFM-2DIR nanospectroscopy enables in situ investigation of vibrational anharmonicity, coupling, and energy transfer in nanostructures.
  • The technique is suitable for unraveling relaxation processes in 2D materials at IR frequencies.
  • This method bridges the gap between high-resolution imaging and detailed molecular spectroscopy.