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Updated: Jun 26, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

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Antibody-Drug Conjugates: A promising breakthrough in cancer therapy

Swapnali Parit1, Ajit Manchare1, Amol D Gholap2

  • 1Institute of Chemical Technology, Marathwada Campus, Jalna 431203, Maharashtra, India.

International Journal of Pharmaceutics
|May 16, 2024
PubMed

Insights

Antibody-drug conjugates (ADCs) offer precise cancer treatment by targeting cytotoxic drugs to tumor cells. Innovations in ADC design are crucial to overcome resistance and improve efficacy.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Antibody-drug conjugates (ADCs) represent a targeted therapy approach for cancer treatment.
  • ADCs selectively deliver cytotoxic payloads to cancer cells, minimizing off-target effects.
  • Challenges such as drug resistance and cancer heterogeneity necessitate further ADC development.

Purpose of the Study:

  • To critically analyze the function mechanisms of ADCs.
  • To highlight advancements in antibody engineering for ADC development.
  • To review clinical progress and approved formulations of ADCs.

Main Methods:

  • Analysis of ADC function mechanisms, including antibody-linker-payload interactions.
  • Examination of antibody engineering advancements for enhanced ADC specificity and potency.
  • Review of clinical trials and approved ADC formulations.

Main Results:

  • ADCs demonstrate high precision and specificity in cancer drug delivery.
  • Innovations in antibody engineering are leading to more potent and selective ADCs.
  • Significant progress has been made in clinical ADC development, with several approved therapies.

Conclusions:

  • ADCs are a vital tool in targeted cancer therapy, offering significant advantages.
  • Continued innovation in molecular design is essential to address resistance and improve patient outcomes.
  • Further research into ADC mechanisms and clinical applications will enhance their therapeutic potential.
Keywords:
Antibody-drug conjugatesAntibody-drug conjugationCancer therapyDrug-to-Antibody RatioLinker moleculeMonoclonal antibodiesPayload

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