[Acute-phase markers in gynecologic tumors]

The serum concentration of 3 acute phase reactants (APR) (Caeruloplasmin, Alpha-1-antitrypsin and C-reactive protein) was measured by Mancini-technique praetherapeutically in a group of 214 patients with different sites of gynecological tumors. A group of 27 healthy women was used for comparison. In benign tumors Caeruloplasmin had in cases of myoma significantly (5%-standard) more elevated levels than normal group. In all cases with malignancies all 3 APR had significantly more elevated levels than in benign tumors. In cases of carcinoma of ovary all 3 APR had significant more elevated levels than benign ovarian tumors. The percentage of praetherapeutically elevated Alpha-1-antitrypsin levels was higher, while the percentage of elevated CRP-levels in cases with benign ovarian tumors ("false positive") was lower in comparison to accepted markers for ovarian cancer. Thus it appears to be indicated to prove the value of measurement of APR for monitoring in gynecological oncology.