Real-World Study of Definisse Threads for Facial Reshaping in Indian Patients: REDEFINE FACE Study

Area of Science:

• Aesthetic Medicine
• Cosmetic Surgery
• Dermatology

Background:

• Thread lifting is a popular, minimally invasive cosmetic procedure for lifting and repositioning sagging tissues.
• Poly-lactic acid-polycaprolactone (PLCL) Definisse threads represent a fourth-generation absorbable suspended barbed thread technology.
• These threads offer dual action: immediate mechanical lift and long-term histological rejuvenation by stimulating collagen, elastin, and hyaluronic acid synthesis.

Purpose of the Study:

• To evaluate the effectiveness and safety of Definisse threads for facial reshaping in a real-world setting.
• To assess patient outcomes and tolerance in the Indian population.

Main Methods:

• A multicenter, retrospective observational study was conducted.
• Included patients underwent facial contouring using Definisse threads (single or combination techniques).
• Outcomes were assessed using the Global Aesthetic Improvement Scale (Physician and Subject).

Main Results:

• 317 patients (mean age 48.6 years) were followed for a mean of 4.9 months.
• Significant improvements in facial reshaping were observed immediately post-treatment and throughout follow-up.
• 96% of patients showed enhancement, with most minor side effects resolving spontaneously.

Conclusions:

• Definisse threads are effective for facial reshaping in Indian patients, providing both immediate and sustained aesthetic improvements.
• The procedure was well-tolerated, with no serious adverse events reported.
• This real-world data supports the efficacy and safety of PLCL Definisse threads for facial rejuvenation.