A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation

Area of Science:

• Cardiovascular Research
• Animal Models
• Cardiac Surgery

Background:

• Functional tricuspid regurgitation (FTR) is the most prevalent form of tricuspid regurgitation (TR).
• Effective experimental models for studying FTR are currently limited.
• A robust animal model is crucial for advancing FTR research.

Purpose of the Study:

• To establish a reliable and effective experimental swine model for functional tricuspid regurgitation.
• To provide a platform for investigating the mechanisms and potential treatments of FTR.

Main Methods:

• A swine model of FTR was created using radiofrequency ablation, atrial septostomy, and induced right atrial volume overload.
• Echocardiography was utilized for baseline and follow-up assessments of FTR progression and cardiac changes.
• Autopsy was performed to confirm tricuspid valve anatomy.

Main Results:

• The developed model demonstrated varying degrees of FTR one month post-intervention (8.3% severe, 66.7% moderate, 25% mild).
• All pigs developed an atrial septal defect (average diameter 1.5 ± 0.5 cm).
• Significant increases in tricuspid annular diameter and right heart enlargement were observed (P < 0.05), with no significant changes in left heart size or mitral regurgitation.

Conclusions:

• A novel and effective swine model for functional tricuspid regurgitation has been successfully developed.
• This model offers a valuable experimental platform for future research into FTR.
• The model facilitates the study of FTR progression and associated cardiac remodeling.