Role of microRNAs in tumor progression by regulation of kinesin motor proteins

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Updated: Jun 26, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

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Arya Nasimi Shad1, Ali Fanoodi2, Amirhosein Maharati1

  • 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

International Journal of Biological Macromolecules
|May 16, 2024
PubMed

Insights

MicroRNAs (miRNAs) primarily act as tumor suppressors by targeting Kinesin superfamily proteins (KIFs), which are crucial for cell division. This miRNA-KIFs axis presents a promising therapeutic target for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Biology

Background:

  • Aberrant cell proliferation is a hallmark of cancer, influenced by cellular processes and signaling pathways.
  • Kinesin superfamily proteins (KIFs) are motor proteins vital for cytoplasmic transport and chromosomal segregation during cell division.
  • Dysregulation of KIFs is implicated in various cancers, highlighting the need for understanding their regulation.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in tumor biology, specifically focusing on their regulation of Kinesin superfamily proteins (KIFs).
  • To explore the potential of the miRNA-KIFs axis as a therapeutic target in cancer treatment.

Main Methods:

  • Literature review of studies investigating miRNAs, KIFs, and their roles in cancer.
  • Analysis of signaling pathways and cellular processes involving miRNA-mediated regulation of KIFs.

Main Results:

  • MicroRNAs (miRNAs) play a significant role in regulating Kinesin superfamily proteins (KIFs).
  • MiRNAs predominantly exhibit tumor suppressor functions through targeting KIFs.
  • The identified miRNA-KIFs axis is crucial for maintaining chromosomal stability and normal cellular homeostasis.

Conclusions:

  • MicroRNAs are key regulators of Kinesin superfamily proteins and are involved in tumor suppression.
  • Targeting the miRNA-KIFs axis offers a potential therapeutic strategy for combating cancer.
Keywords:
DiagnosisKinesinMarkerTreatmentcancermicroRNA

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