Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Light-switchable swarming of biohybrid microrobots.

Science advances·2026
Same author

SERS-Based Nano- and Microsystems Toward Biomedical Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Method of oral delivery affects vitamin C-mediated alleviation of colitis in a mouse model.

Gut microbes reports·2026
Same author

Fungal Mycelium Films Engineered as Renewable Fibrous Materials for Drug Delivery.

ACS applied materials & interfaces·2026
Same author

Fabrication and characterization of enteric microneedle patches for oral delivery of small and macromolecule compounds.

International journal of pharmaceutics·2025

Related Experiment Video

Updated: Jul 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.8K

Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery.

Reece McCabe1, Lasse Højlund Eklund Thamdrup1, Mahdi Ghavami1

  • 1The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.

ACS Applied Bio Materials
|May 16, 2024
PubMed
Summary

Researchers developed a biodegradable elastomer, polyoctanediol citrate (POC), for oral drug delivery devices. This sustainable material shows promise for creating advanced foil-type devices for enhanced macromolecule delivery.

Keywords:
biodegradable elastomermacromoleculesoral deviceoral drug deliverypolymer

More Related Videos

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.5K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.1K

Related Experiment Videos

Last Updated: Jul 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.8K
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.5K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.1K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Foil-type oral devices offer potential for delivering poorly permeable macromolecules via unidirectional release in the intestines.
  • A key limitation of current foil-type devices is the use of non-biodegradable elastomers, posing environmental concerns.

Purpose of the Study:

  • To synthesize and characterize a novel biodegradable elastomer for fabricating environmentally friendly foil-type oral drug delivery devices.
  • To evaluate the mechanical properties, surface characteristics, and drug release performance of devices made from the new material.

Main Methods:

  • Synthesis of polyoctanediol citrate (POC) via a one-pot reaction.
  • Microscale pattern replication using casting to create foil-type device structures.
  • Mechanical testing (elastic modulus, strain at failure), surface free energy evaluation, and degradation studies.
  • Loading devices with acetaminophen, enteric coating, and in vitro drug release testing in simulated gastric and intestinal fluids.

Main Results:

  • The synthesized POC elastomer exhibited suitable mechanical properties (elastic modulus up to 2.2 MPa, strain at failure up to 110%).
  • Acetaminophen-loaded, enterically coated devices demonstrated complete drug release within 2.5 hours under simulated physiological conditions.
  • The material showed promising characteristics in terms of surface free energy and degradation behavior.

Conclusions:

  • Polyoctanediol citrate (POC) is a viable biodegradable alternative to non-biodegradable elastomers for foil-type oral drug delivery devices.
  • The developed material and device fabrication method support sustainable and effective delivery of pharmaceuticals.
  • Further research is warranted to explore the full potential of POC-based devices for macromolecule delivery.