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Therapeutics Pipeline

Lauren Sauer1, Alice Sato2, Herbert Dele Davies3

  • 1GCHS, Special Pathogen Research Network, Department of Environmental, Agricultural and Occupational Health, UNMC College of Public Health, 984355 Nebraska Medical Center, Omaha, NE, USA.

Pediatric Clinics of North America
|May 16, 2024
PubMed

Insights

Developing medical countermeasures (MCMs) for children presents unique challenges due to their distinct needs. The coronavirus disease 2019 pandemic accelerated the need for a robust pediatric MCM pipeline.

Area of Science:

  • Pediatric pharmacology
  • Infectious disease therapeutics
  • Public health preparedness

Background:

  • Children possess unique physiological, developmental, and psychosocial characteristics, complicating therapeutic development.
  • Pandemic and outbreak scenarios exacerbate the challenges of creating effective pediatric medical countermeasures (MCMs).
  • Past decade has seen progress, but the coronavirus disease 2019 pandemic highlighted critical gaps in pediatric MCM development.

Purpose of the Study:

  • To address the inherent challenges in developing medical countermeasures (MCMs) for pediatric populations.
  • To emphasize the necessity of a dedicated MCM pipeline for children.
  • To highlight the unique considerations required for pediatric therapeutic development during public health emergencies.

Main Methods:

  • Review of existing literature on pediatric drug development and MCMs.
  • Analysis of challenges specific to pediatric populations during health crises.
  • Examination of advancements spurred by the coronavirus disease 2019 pandemic.

Main Results:

  • Pediatric-specific physiological and developmental differences pose significant hurdles for MCM development.
  • The urgent nature of pandemics necessitates tailored approaches for pediatric MCMs.
  • The coronavirus disease 2019 pandemic underscored the need for accelerated pediatric MCM research and development.

Conclusions:

  • A robust pipeline for pediatric medical countermeasures is essential for effective public health response.
  • Addressing the unique vulnerabilities of children is paramount in therapeutic development.
  • Future efforts must prioritize pediatric considerations in the design and implementation of MCMs.

Keywords:
AntiviralsDrug pipelineFormulationsMedical countermeasuresMonoclonal antibodiesPhysiologyPolyclonal preparationsTherapeutics

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