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LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa
Bruna De Felice1, Pasquale De Luca2, Concetta Montanino1
1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy.
Molecular Medicine Reports
|May 17, 2024
Summary
Long noncoding RNAs (lncRNAs) play roles in skin health and disease. Three specific lncRNAs (lncRNA-TINCR, lncRNA-RBM5-ASI1, and lncRNA-MRPL23-AS1) are overexpressed in hidradenitis suppurativa (HS), offering potential diagnostic and therapeutic targets.
Area of Science:
- Molecular biology
- Dermatology
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are implicated in various physiological and pathological processes, including cutaneous diseases.
- Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin condition affecting approximately 1% of the global population, with partially understood pathogenesis involving immune dysregulation.
Purpose of the Study:
- To investigate the biological relevance of lncRNAs in the pathogenesis of hidradenitis suppurativa (HS).
- To identify potential lncRNA biomarkers and therapeutic targets for HS.
Main Methods:
- Differential expression analysis of lncRNAs and messenger RNAs (mRNAs) in HS patients.
- Construction of a lncRNA-microRNA regulatory network.
- Validation of lncRNA expression using reverse transcription-quantitative PCR (RT-qPCR).
Main Results:
- Three lncRNA expression signatures, specifically lncRNA-TINCR, lncRNA-RBM5-ASI1, and lncRNA-MRPL23-AS1, were found to be significantly overexpressed in patients with HS compared to healthy controls.
- These lncRNAs are implicated in the regulatory network of HS pathogenesis.
Conclusions:
- The identified lncRNAs (lncRNA-TINCR, lncRNA-RBM5-ASI1, and lncRNA-MRPL23-AS1) show potential as prognostic predictors for HS.
- These findings contribute to understanding HS pathogenic mechanisms and may offer novel therapeutic targets for the disease.
