Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

158
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
158
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

177
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
177
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

240
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
240
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

237
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
237
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

322
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
322
Tonsillitis II: Management01:26

Tonsillitis II: Management

110
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
110

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benign Solitary Schwannoma of the Cheek: A Case Report and a Review of the Literature.

Ear, nose, & throat journal·2024
Same author

Parotid abscess causing facial palsy in a child: A case report.

International journal of surgery case reports·2024
Same author

An unusual penetrating cervical wound involving a disc grinder: A case report.

International journal of surgery case reports·2024
Same author

Case Series: Pleomorphic adenoma in minor salivary gland.

F1000Research·2024
Same author

Intrathyroid thyroglossal duct cyst: A case report.

International journal of surgery case reports·2024
Same author

Dubin-Johnson syndrome in Tunisia: Spectrum of a rare disease.

Presse medicale (Paris, France : 1983)·2018
Same journal

Progressive Epiglottic Deformity and Acute Supraglottic Edema: A Fatal Combination in Behçet's Disease.

Ear, nose, & throat journal·2026
Same journal

Should a Tissue Cuff Be Preserved During Auricular Lobule Keloid Excision to Reduce Recurrence?

Ear, nose, & throat journal·2026
Same journal

Middle Turbinate Fibroepithelial Polyp as a Developmental Anomaly of the Nasal Cavity: A Case Report and Review of the Literature.

Ear, nose, & throat journal·2026
Same journal

Eggshell-like Intraosseous Cyst of the Ethmoid Perpendicular Plate: Imaging Clues and Endoscopic Management.

Ear, nose, & throat journal·2026
Same journal

Thyroiditis With IgG4 Plasma Cells.

Ear, nose, & throat journal·2026
Same journal

GLP-1 Receptor Agonists and THRIVE-Assisted Airway Surgery: The Need for Procedure-specific Evidence.

Ear, nose, & throat journal·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

125

Primary Peritonsillar Tuberculosis in a Rheumatoid Arthritis Patient Treated With Methotrexate.

Samia Meherzi1,2, Amin Khbou1,2, Rihab Omri1,2

  • 1ENT Department, Hospital of Sidi Bouzid, Sidi Bouzid, Tunisia.

Ear, Nose, & Throat Journal
|May 17, 2024
PubMed
Summary
This summary is machine-generated.

Methotrexate treatment for rheumatoid arthritis can reactivate tuberculosis, presenting as tonsil ulcers and lymphadenopathy. Successful treatment involves antitubercular therapy and methotrexate discontinuation.

Keywords:
lymph node involvementmethotrexatetonsillar tuberculosistuberculosis

More Related Videos

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.2K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

75

Related Experiment Videos

Last Updated: Jun 26, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

125
Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.2K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

75

Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • Methotrexate is a common immunosuppressant for rheumatoid arthritis.
  • Immunosuppression can increase the risk of opportunistic infections, including tuberculosis.
  • Reactivation of latent tuberculosis is a concern in patients on long-term immunosuppressive therapy.

Purpose of the Study:

  • To report a case of tuberculosis reactivation in a rheumatoid arthritis patient treated with methotrexate.
  • To highlight the diagnostic challenges and treatment course of this condition.
  • To emphasize the importance of considering tuberculosis in patients with relevant symptoms during immunosuppressive therapy.

Main Methods:

  • Case report of a 48-year-old male with rheumatoid arthritis.
  • Diagnostic workup including tonsillar biopsy and microbiological examination.
  • Treatment with antitubercular therapy and management of methotrexate dosage.

Main Results:

  • The patient presented with tonsillar ulceration and cervical lymphadenopathy.
  • Tonsillar biopsy confirmed tuberculosis.
  • Recurrence of symptoms upon methotrexate resumption, resolving after its discontinuation and completion of antitubercular therapy.

Conclusions:

  • Methotrexate therapy for rheumatoid arthritis can lead to tuberculosis reactivation.
  • Prompt diagnosis and appropriate antitubercular treatment are crucial.
  • Discontinuation of methotrexate may be necessary for successful management of tuberculosis in such cases.