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Updated: Jun 26, 2025
08:43
Imaging of the Microstructural Failure Mechanism in the Human Hip
Published on: September 29, 2023
828
Fracture behavior of human cortical bone with high glycation content under dynamic loading
Ebrahim Maghami1, Amirreza Sadighi1, Ahmad R Najafi1
1Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USA.
Summary
Diabetic bone fracture is simulated using advanced glycation end-products (AGEs). Increased AGEs alter bone
Area of Science:
- Biomechanics
- Materials Science
- Orthopedics
Background:
- Diabetes mellitus is associated with increased bone fragility.
- Advanced glycation end-products (AGEs) accumulate in diabetic bone, potentially altering its mechanical properties.
- Understanding the fracture behavior of diabetic bone under dynamic loading is crucial for preventing fractures.
Purpose of the Study:
- To simulate the fracture behavior of diabetic cortical bone with high AGEs levels under dynamic loading.
- To investigate the role of AGEs-induced material heterogeneity on crack initiation and propagation.
- To explore the influence of microstructural features on the fracture response of diabetic bone.
Main Methods:
- A phase field fracture framework was implemented.
- 2D models of human tibia cortical microstructure were used.
- Simulations were performed under dynamic loading conditions.
Main Results:
- Increased AGEs content reduces the critical energy release rates of microstructural features, degrading material heterogeneity.
- Mismatches in fracture properties between osteons and interstitial tissue due to AGEs affect crack trajectories and branching.
- Cortical microstructural features like osteons and cement lines can mitigate multiple cracking.
- Dynamic loading can activate/deactivate toughening mechanisms depending on AGEs content.
Conclusions:
- The interplay between loading type and material heterogeneity significantly influences the fracture response of diabetic cortical bone.
- AGEs contribute to altered fracture behavior and increased fragility in diabetic bone.
- Microstructural features play a protective role against complex fracture patterns under dynamic loading.
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