Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimal pace timing for left bundle branch area pacing with or without an additional LV lead: results from the CSPOT study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026

Same author

Left Bundle Branch Area Pacing: Does Lead Position Matter?

JACC. Clinical electrophysiology·2026

Same author

Radiofrequency current-facilitated implantation of left bundle branch pacing lead for cardiac resynchronization therapy.

Heart rhythm·2026

Same author

Catheter Ablation of atrial fibrillation vs. atrioventricular nodal ablation with Conduction system pacing in persistent atrial fibrillation and heart failure (ABACUS): rationale and design.

European heart journal open·2026

Same author

Characterization of a K-type side-hole polarization-maintaining fiber for simultaneous distributed pressure and temperature sensing.

Optics express·2026

Same author

Beyond classifications: Pregnancy associated with a structural abnormality of the left ventricle.

Kardiologia polska·2026

Search research articles

Related Experiment Video

Updated: Jun 26, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Strength-duration curves for left bundle branch area pacing.

Grzegorz Kiełbasa¹, Marek Jastrzębski², Agnieszka Bednarek¹

¹First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland; First Department of Cardiology, Interventional Electrocardiology and Hypertension University Hospital in Krakow, Krakow, Poland.

|May 17, 2024

Summary

Left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP) show similar chronaxie and rheobase values. This study provides crucial data for optimizing LBBP device programming, including pulse duration and battery longevity.

Keywords:

Battery consumption Chronaxie Left bundle branch area pacing Rheobase Strength–duration curve

More Related Videos

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Published on: November 7, 2019

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jun 26, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Published on: November 7, 2019

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

Area of Science:

Cardiology
Electrophysiology
Medical Devices

Background:

Left bundle branch pacing (LBBP) is increasingly used clinically.
Fundamental pacing parameters like chronaxie and rheobase for LBBP are not well-established.

Purpose of the Study:

To determine strength-duration curves, chronaxie, and rheobase for LBBP and left ventricular septal pacing (LVSP).
To analyze battery current drain and selective LBBP at short pulse durations (PD).

Main Methods:

Strength-duration curves were calculated for 141 patients with permanent LBBP and LVSP at six different PDs.
Battery current drain and selective LBBP were assessed.
LBBP data were compared with prior His-bundle pacing (HBP) data from 127 patients.

Main Results:

LBBP and LVSP demonstrated similar chronaxie (0.38 vs 0.39 ms) and identical rheobase values (0.27 V).
LBBP chronaxie was significantly lower than HBP (0.38 vs 0.53 ms), with similar rheobase values.
Selective LBBP capture occurred in 19% and 41% of patients at PDs of 0.06 ms and 0.03 ms, respectively.
Lowest battery current drain was observed at a PD of 0.2 ms with a +1 V safety margin.

Conclusions:

Strength-duration curves for LBBP and LVSP offer insights into optimizing pacing device programming.
Findings guide optimal selection of pulse duration, voltage amplitude, and battery longevity for LBBP.
Data aids in understanding and achieving selective capture with LBBP devices.