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Updated: Jun 26, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

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The roles of B cells in cardiovascular diseases

Jian Ma1, Xiaotong Wang2, Yuewang Jia1

  • 1Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Molecular Immunology
|May 19, 2024
PubMed

Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGFβ1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.

Keywords:
B cellsCardiac remodelingFibrosisHeart diseasesTherapy

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