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Related Concept Videos

¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

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The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
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¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

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When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
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Carbon-13 (¹³C) NMR: Overview01:10

Carbon-13 (¹³C) NMR: Overview

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Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...
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Related Experiment Video

Updated: Jun 26, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

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Published on: December 30, 2016

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Data Format Standardization and DICOM Integration for Hyperpolarized 13C MRI.

Ernesto Diaz1, Renuka Sriram1, Jeremy W Gordon1

  • 1Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.

Arxiv
|May 20, 2024
PubMed
Summary
This summary is machine-generated.

Standardizing data storage for hyperpolarized (HP) 13C MRI is crucial for multi-site trials. This study proposes a minimum data set and demonstrates DICOM standard utilization for HP 13C MRI data.

Keywords:
DICOM formatExperiment metadataHyperpolarized 13C MRImetabolic imaging

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Area of Science:

  • Medical Imaging
  • Metabolic Imaging
  • Magnetic Resonance Imaging

Background:

  • Hyperpolarized (HP) 13C MRI enables in vivo metabolic measurements and is expanding globally with human trials.
  • Standardized data storage is essential for comparing data across multiple research sites.

Conclusions:

  • The DICOM standard offers a flexible and suitable framework for storing HP 13C MRI data.
  • Standardized data storage using DICOM will facilitate data comparison and collaboration across research sites.
  • The proposed methods and best practices will support the growth and development of HP 13C MRI research.