Eco-Friendly Spiking Approach Based on Microfluidics for Preparation of Matrix Reference Materials

Area of Science:

• Analytical Chemistry
• Materials Science
• Environmental Science

Background:

• Medicated baths are standard for developing aquatic product reference materials.
• Traditional methods generate problematic liquid waste requiring treatment.
• Environmental concerns necessitate sustainable alternatives in reference material preparation.

Purpose of the Study:

• To develop an environmentally friendly spiking method for aquatic product reference materials.
• To improve drug utilization and loading capacity compared to conventional techniques.
• To create stable, controllable matrix reference materials with reduced environmental impact.

Main Methods:

• Utilized microfluidic technology to create minced fish gel microspheres.
• Mixed minced fish samples with quinolone drugs.
• Leveraged the water-locking property of gel microspheres for enhanced drug loading.

Main Results:

• Achieved a 2.33-4.03 times increase in matrix drug-loading capacity.
• Demonstrated good stability of the prepared matrix reference material.
• Confirmed adjustable and controllable drug concentrations in the reference material.

Conclusions:

• The microfluidic-based method offers a sustainable and efficient approach for reference material preparation.
• This technique significantly enhances drug loading and stability while mitigating environmental issues.
• The method provides precise control over drug concentration, suitable for various applications.