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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Related Experiment Video

Updated: Jun 26, 2025

Rapid, Seamless Generation of Recombinant Poxviruses using Host Range and Visual Selection
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Valoctocogene Roxaparvovec.

Terri L Levien1, Danial E Baker1

  • 1Washington State University, Spokane, WA, USA.

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Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs and utilization evaluations for Pharmacy & Therapeutics Committees. This service aids in drug review and informed medication use decisions for healthcare facilities.

Keywords:
drug informationformulary management/P & Tgene therapy

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Area of Science:

  • Pharmaceutical Sciences
  • Health Services Research

Background:

  • Pharmacy & Therapeutics (P&T) Committees require timely and accurate drug information.
  • Evaluating drug utilization is crucial for optimizing patient care and managing costs.

Purpose of the Study:

  • To describe the features and benefits of The Formulary Monograph Service.
  • To highlight the service's utility for P&T Committees and healthcare professionals.

Main Methods:

  • The service delivers 5-6 detailed monographs on new or late-phase drugs monthly.
  • Includes 1-page summary monographs for quick reference and drug utilization evaluations (DUE/MUE).

Main Results:

  • Subscribers receive comprehensive drug information and utilization reviews.
  • Monographs are accessible online and can be customized for specific facility needs.

Conclusions:

  • The Formulary Monograph Service supports evidence-based formulary management.
  • It provides valuable resources for informed drug selection and medication use evaluation.