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Updated: Jun 26, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder
Noy Bagdadi1, Abed N Azab2,3, Rachel Shvartsur2,3
1Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Israel.
Abstract:
Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient's quality of life and causes significant morbidity and mortality. Although there are a variety of available treatments, therapeutic intervention is not beneficial in many cases and recurrence rates remain high. Recent data suggested tamoxifen, a drug with a wide range of activities, as a potential treatment for reducing manic symptoms of BD. Tamoxifen's therapeutic effect on bipolar mania has not been fully elucidated, but it is believed to biochemically operate on protein kinase C (PKC) inhibition. In this article, we review preclinical and clinical studies investigating the efficacy of tamoxifen as a potential treatment for bipolar manic patients.
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