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Updated: Jun 26, 2025

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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Published on: June 23, 2022

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Post-translational Modification of α-Synuclein Modifies Monomer Dynamics and Aggregation Kinetics

Kasun Gamage, Binyou Wang, Eldon R Hard

    Biorxiv : the Preprint Server for Biology
    |May 20, 2024
    PubMed
    Summary

    Posttranslational modifications, like O-GlcNAcylation, impact alpha-Synuclein aggregation differently. Glycosylation at T72 slows aggregation, while S87 may accelerate early stages, showing modifications don't uniformly affect protein clumping in neurodegenerative diseases.

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