Related Experiment Video

Updated: Jun 26, 2025

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines
10:16

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines

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Response to dabrafenib plus trametinib on a rare BRAF mutation (V600_W604 deletion-insertion R) in an advanced

Akiko Tamura1, Ryoko Inaba Higashiyama1, Tatsuya Yoshida1

  • 1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Thoracic Cancer
|May 20, 2024
PubMed

Insights

Dabrafenib plus trametinib shows efficacy in advanced non-small cell lung cancer (NSCLC) with uncommon BRAF mutations. Comprehensive genomic profiling is crucial for identifying these rare alterations.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • BRAF V600E mutations are common drivers in lung adenocarcinoma, with targeted therapies like dabrafenib plus trametinib approved for advanced NSCLC.
  • Efficacy data for dabrafenib plus trametinib against rare BRAF mutations in NSCLC are limited due to their infrequent occurrence.
Keywords:
BRAF V600_W604 deletion–insertion RBRAF mutationcomprehensive genomic profilingdabrafenib plus trametiniblung adenocarcinoma

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