Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body Composition and Body Mass Index Show Comparable Associations with Adalimumab Exposure and Immunogenicity in Noninfectious Uveitis.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2026
Same author

Uveitis in spondyloarthritis: clinical patterns and differences between axial and peripheral forms.

Clinical rheumatology·2026
Same author

Clinical experience with gene therapy for autosomal recessive RPE65-related retinal dystrophy in the Arabian Gulf.

Ophthalmology. Retina·2026
Same author

A Case Report of Presumed West Nile Virus Chorioretinitis in a Non-Endemic Area: Atypical Serology and Imaging Features of Old and New Lesions.

Case reports in ophthalmology·2026
Same author

Evidence and Consensus-Based Guidelines in Vogt-Koyanagi-Harada Disease. Multimodal Imaging in Uveitis (MUV) Taskforce Report 16.

Ophthalmology. Retina·2026
Same author

Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis.

PloS one·2026
Same journal

The Role of Nrf2 in SIRT1-Mediated RGC Neuroprotection in Traumatic Optic Neuropathy.

Translational vision science & technology·2026
Same journal

Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.

Translational vision science & technology·2026
Same journal

Preclinical Safety and Feasibility Study of Line-Field Confocal Optical Coherence Tomography for Ophthalmology Applications.

Translational vision science & technology·2026
Same journal

Pathogenicity Analysis of Two Novel CRB1 Mutations in Three Chinese Inherited Retinal Dystrophy Families and a Literature Review.

Translational vision science & technology·2026
Same journal

Gas-Lesion Contact and Postural Compliance After Vitrectomy With Tamponade: A Continuous Monitoring and 3D Quantitative Analysis.

Translational vision science & technology·2026
Same journal

Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.

Translational vision science & technology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

4.8K

Vitreoretinal Interface Cells Correlate In Vivo With Uveitis Activity and Decrease With Anti-Inflammatory Treatment.

Francesco Pichi1,2, Piergiorgio Neri1,2, Shaikha Aljneibi1

  • 1Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Translational Vision Science & Technology
|May 20, 2024
PubMed
Summary
This summary is machine-generated.

En face swept-source optical coherence tomography angiography (SS-OCTA) effectively visualizes vitreoretinal interface cells (VRICs) in active uveitis. This imaging technique reveals significant changes in VRIC number and size during inflammation and recovery, offering new therapeutic targets.

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.7K
Characterization of a Novel Human Organotypic Retinal Culture Technique
05:51

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

4.0K

Related Experiment Videos

Last Updated: Jun 25, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

4.8K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.7K
Characterization of a Novel Human Organotypic Retinal Culture Technique
05:51

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

4.0K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Cell Biology

Background:

  • Uveitis is an inflammatory condition affecting the eye.
  • Vitreoretinal interface cells (VRICs) play a role in ocular inflammation.
  • Accurate assessment of VRICs is crucial for managing uveitis.

Purpose of the Study:

  • To evaluate the utility of en face swept-source optical coherence tomography angiography (SS-OCTA) in assessing vitreoretinal interface cells (VRICs).
  • To analyze the dynamics of VRICs in patients with active uveitis.
  • To correlate VRIC measurements with clinical indicators of inflammation.

Main Methods:

  • Prospective, single-center study involving 20 eyes with active uveitis.
  • Six 6x6-mm macular scans were acquired at three time points: active inflammation, improving, and resolved inflammation.
  • VRICs were visualized using 3-µm en face OCT slabs on the inner limiting membrane.

Main Results:

  • Baseline VRIC count and density were significantly higher in uveitis patients compared to healthy controls.
  • VRIC number and density significantly decreased as inflammation improved (P = 0.007).
  • VRIC size reduced during improvement (P = 0.009) and correlated with inflammatory parameters.

Conclusions:

  • En face SS-OCTA effectively demonstrates increased VRIC number and size in active uveitis, likely due to monocyte recruitment.
  • VRIC parameters normalized post-inflammation, indicating the imaging modality's sensitivity to disease activity.
  • In vivo OCT visualization of VRICs presents potential for novel therapeutic strategies in uveitis management.