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Updated: Jun 25, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Nocturnal heat exposure and stroke risk
Cheng He1, Susanne Breitner1,2, Siqi Zhang1
1Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany.
Extreme nighttime heat increases stroke risk, particularly for older individuals, females, and those with mild symptoms. This risk has grown over time, highlighting the impact of climate change on cardiovascular health.
Area of Science:
- Environmental Health
- Cardiovascular Epidemiology
- Climate Change Impact
Background:
- Nighttime temperatures are rising faster than daytime temperatures globally.
- Increased nocturnal heat exposure is a potential cardiovascular health risk.
- This study examines the link between nighttime heat and stroke risk in Germany.
Purpose of the Study:
- To investigate the association between nighttime heat exposure and stroke risk.
- To analyze temporal variations in this association over 15 years.
- To identify subgroups with increased vulnerability to nocturnal heat.
Main Methods:
- Utilized hourly meteorological data and a dataset of 11,037 stroke cases (2006-2020).
- Employed time-stratified case-crossover analysis with a distributed lag non-linear model.
- Controlled for maximum daytime temperature and other climatic variables; performed subgroup analyses.
Main Results:
- Extreme nighttime heat (97.5th percentile of HNE) significantly increased stroke risk (OR 1.07).
- Nighttime heat-related stroke risk, especially for ischemic strokes, increased significantly in the later study period (2013-2020 vs. 2006-2012).
- Older individuals, females, and those with mild stroke symptoms showed heightened vulnerability.
Conclusions:
- Nocturnal heat exposure is linked to elevated stroke risk, independent of daytime maximum temperature.
- Susceptibility to nighttime heat has increased between 2006 and 2020.
- Nocturnal heat is a critical stroke trigger in a warming climate, necessitating targeted public health interventions.
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