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Intraocular pressure changes with propofol ('Diprivan'): comparison with thiopentone
Postgraduate Medical Journal
|January 1, 1985
Summary
Propofol and thiopentone significantly reduce intraocular pressure (IOP). Propofol caused a greater IOP reduction but was associated with more adverse effects like decreased blood pressure.
Area of Science:
- Anesthesiology
- Ophthalmology
- Pharmacology
Background:
- Intraocular pressure (IOP) management is critical in anesthesia.
- Non-barbiturate anesthetic agents offer potential alternatives for IOP control.
Purpose of the Study:
- To compare the effects of propofol and thiopentone on intraocular pressure.
- To evaluate propofol's efficacy and safety in reducing IOP.
Main Methods:
- Prospective study measuring IOP using an applanation tonometer.
- Comparison of induction doses of propofol versus thiopentone.
- Inclusion of 66% nitrous oxide in oxygen inhalation.
Main Results:
- Both propofol and thiopentone significantly decreased IOP.
- Propofol achieved a maximum IOP reduction of 53%, compared to 40% with thiopentone.
- Propofol use correlated with decreased arterial pressure and injection site pain in 25% of patients.
Conclusions:
- Propofol is effective in lowering intraocular pressure, surpassing thiopentone's effect.
- Anesthetic-induced IOP reduction is achievable with propofol.
- Potential side effects of propofol, including hypotension and injection pain, require consideration.