Related Experiment Video
Updated: Jul 6, 2026
08:08
Automated Measurement of Cryptococcal Species Polysaccharide Capsule and Cell Body
Published on: January 11, 2018
7.3K
Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang1, Ruiying Hao1, Xin Liu2
1School of Clinical Medicine, The Hebei University of Engineering, Handan, Hebei, China.
Frontiers in Immunology
|May 22, 2024
Summary
This bibliometric analysis maps global Cryptococcus research over ten years, identifying key institutions, authors, and emerging trends in host immune system interactions. It highlights current foci and future research directions in this critical field.
Area of Science:
- * Mycology and Immunology: Investigating the complex interplay between fungal pathogens and host defense mechanisms.
- * Bibliometrics: Applying quantitative analysis to map scientific literature and research trends.
Background:
- * Global prevalence and impact of *Cryptococcus* species necessitate a comprehensive understanding of host-pathogen dynamics.
- * Previous research has not systematically analyzed the evolving landscape of *Cryptococcus* and host immunity studies.
Purpose of the Study:
- * To conduct a systematic bibliometric analysis of global research on *Cryptococcus* species and their interactions with the host immune system over the past decade (2013-2023).
- * To identify leading research institutions, countries, prolific authors, key journals, and emerging research themes in this field.
- * To provide insights into current research trajectories and inform future scientific inquiries.
Main Methods:
- * Systematic literature search of publications related to *Cryptococcus* and host immunity within the Web of Science Core Collection database.
- * Bibliometric analysis and visualization using VOSviewer and CiteSpace software platforms.
- * Analysis of publication volume, citations, influential institutions, countries, authors, and journals.
Main Results:
- * A total of 795 publications were identified between October 1, 2013, and October 1, 2023.
- * Leading institutions include Duke University, University of Minnesota, and University of Sydney; top countries are the United States, China, and Brazil.
- * Key authors identified are Casadevall, Arturo; Wormley, Floyd L., Jr.; and Olszewski, Michal A. The most cited author is Perfect, Jr. Mbio is the leading journal.
- * Research focuses on *Cryptococcus* pathogenesis, host immune responses, complications, and immunotherapies.
Conclusions:
- * This study provides the first comprehensive bibliometric review of *Cryptococcus* research and host immune system interactions.
- * The analysis reveals key players and focal points, offering a roadmap for future research directions.
- * Understanding these dynamics is crucial for developing effective diagnostic and therapeutic strategies against *Cryptococcus* infections.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:22Microbial Interactions: Parasitism
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
01:28Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
01:25Colonisation of Pathogens
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
01:20Determinants of Bacterial Pathogenicity and Virulence
Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...