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The causal relationship between gut microbiota and lymphoma: a two-sample Mendelian randomization study.
Biyun Li1, Yahui Han2, Zhiyu Fu1
1Department of Pediatric Hematology Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in Immunology
|May 22, 2024
Summary
This study used Mendelian randomization to investigate the gut microbiome
Area of Science:
- Microbiome research
- Oncology
- Genetics
Background:
- The gut microbiota's role in lymphoma development is not fully understood.
- Previous research suggests a potential association, but causal links remain unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and five types of lymphoma.
- To identify specific microbial taxa associated with lymphoma development or protection.
Main Methods:
- Two-sample Mendelian randomization (MR) analysis.
- Utilized microbiome data from 14,306 participants and lymphoma data from 324,650 cases.
- Employed five MR methodologies and sensitivity analyses to ensure robust findings.
Main Results:
- Identified 38 potential causal associations between gut microbes and lymphoma.
- Genus Coprobacter showed a protective effect against Hodgkin's lymphoma.
- Genus Alistipes was protective against diffuse large B-cell lymphoma.
- Genus Ruminococcaceae showed protective effects against follicular lymphoma.
- Genus LachnospiraceaeUCG001 was protective against T/NK cell lymphoma.
Conclusions:
- Established a causal link between gut microbiota and lymphoma development.
- Highlighted specific microbial taxa with potential roles in lymphomagenesis.
- Identified potential probiotic candidates for lymphoma treatment and pathogenesis research.
