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Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study
Gabriela Caramano de Oliveira1, Mariangela Torreglosa Ruiz Cintra2, Marco Fábio Prata Lima3
1Universidade Federal do Triângulo Mineiro - Uberaba (MG), Brazil.
Objective:
The aim of this study was to determine the allelic and genotypic frequencies of the polymorphisms, rs2910164 miR-146a and rs11614913 miR-196a2, by investigating their association with endometriosis.
Methods:
This is a case-control study performed with approximately 120 women. The polymorphisms were determined by real-time polymerase chain reaction. For the statistical analysis, the chi-square and logistic regression tests were used.
Results:
There were no significant differences in the genotype and allele frequencies of rs2910164 and rs11614913 between cases and controls. The frequencies in both polymorphisms are in accordance with Hardy-Weinberg equilibrium regarding miR-146a (patients: χ2=1.64, p=0.20; controls: χ2=0.25, p=0.62) and miR-196a2 (patients: χ2=0.58, p=0.44; controls: χ2=2.78, p=0.10). No relationship was observed between rs2910164 and rs11614913 and endometriosis in the inheritance models analyzed.
Conclusion:
In this study, our results show that the studied polymorphisms are not implicated in the development of endometriosis.
