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Identifying non-genetic factors associated with trigger finger.
Leon Guggenheim1, Youngjoo Kang1, Dominic Furniss2
1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7LD, UK.
Summary
Trigger finger (TF) is strongly associated with diabetes, carpal tunnel syndrome, and Dupuytren's disease. This large study confirms known risk factors and reveals new links, aiding in understanding TF pathophysiology.
Area of Science:
- Medical research
- Epidemiology
- Orthopedics
Background:
- Non-genetic factors for trigger finger (TF) have been studied in small cohorts.
- This study provides a comprehensive analysis of TF associations using a large population-based dataset.
Purpose of the Study:
- To identify and quantify the strength of associations between phenotypic variables and trigger finger (TF).
- To provide a more complete picture of TF risk factors and their interrelationships.
Main Methods:
- Case-control study utilizing cross-sectional data from the UK Biobank.
- Multivariable logistic regression was employed to analyze associations between numerous phenotypic factors and TF.
Main Results:
- TF showed significant associations with age, female sex, body mass index, carpal tunnel syndrome, Dupuytren's disease, diabetes mellitus, HbA1c levels, hypothyroidism, and rheumatoid arthritis.
- Strong associations were observed with carpal tunnel syndrome (OR 9.59) and Dupuytren's disease (OR 4.89).
Conclusions:
- The study confirms established risk factors for TF including diabetes, carpal tunnel syndrome, age, and female sex.
- Novel associations with Dupuytren's disease were identified, suggesting a shared pathophysiology with TF, independent of carpal tunnel syndrome.
Keywords:
Carpal tunnel syndromeCase-control studiesCross-sectional studiesDupuytren contractureRisk factorsTrigger finger disorderMore Related Videos
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