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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Related Experiment Video

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D and cancer.

Ranjana P Bird1

  • 1School of Health Sciences, University of Northern British Columbia, Prince George, BC, Canada.

Advances in Food and Nutrition Research
|May 22, 2024
PubMed
Summary

Vitamin D shows potential in preventing cancer, with evidence from observational and preclinical studies. Further research is needed to understand its complex mechanisms and optimize its role in cancer control strategies.

Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • The role of vitamin D in chronic disease prevention, particularly cancer, is a significant area of research.
  • Cancer encompasses a wide range of diseases with complex biological underpinnings.
  • Observational studies and preclinical models suggest a link between vitamin D and cancer prevention.

Purpose of the Study:

  • To review the current understanding of vitamin D's role in cancer prevention.
  • To explore the diverse biological responses and tissue-specific effects of vitamin D.
  • To identify knowledge gaps and future research directions for vitamin D in cancer control.

Main Methods:

  • Review of ecological studies.
  • Analysis of observational data.
Keywords:
Vitamin D and cancerVitamin D and cancer controversyVitamin D in an oncogenic environment

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  • Examination of preclinical models and molecular mechanisms.

    • Main Results:

    • Vitamin D exhibits varied biological effects depending on the tissue.
    • Human factors can influence vitamin D's bioactivity.
    • Mechanisms of vitamin D's anti-carcinogenic effects are multifaceted, involving multiple systems.

    Conclusions:

    • The oncogenic environment can interfere with vitamin D's anti-cancer functions.
    • Significant gaps remain in understanding vitamin D's precise role in cancer.
    • Further research is crucial to integrate vitamin D into effective cancer prevention strategies.