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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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Factors that Influence Healthcare Professionals' Intentions towards Biosimilars.

Mohammed Al Qahtani1, Ahmed Al-Jedai2, Albert Wertheimer3

  • 1Security Forces Hospital-Dammam, Saudi Arabia.

Innovations in Pharmacy
|May 23, 2024
PubMed
Summary

Healthcare professionals in the U.S. show varied intentions towards using biosimilars. Education on biosimilar manufacturing is crucial for physicians and pharmacists, particularly those new to practice, to ensure appropriate use and standardize legislation.

Keywords:
TPBbeliefsbiologic-naive patientsbiosimilarshealthcare intentionperceptions

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Area of Science:

  • Pharmacoeconomics and Health Policy
  • Pharmaceutical Sciences
  • Clinical Pharmacy Practice

Background:

  • Physicians often default to original biologics, hesitant to switch patients to biosimilars despite their high similarity to approved biologics.
  • Healthcare professionals' reluctance to transition patients to biosimilars necessitates an investigation into influencing factors.
  • Understanding these factors is key to increasing biosimilar adoption in the U.S. healthcare system.

Purpose of the Study:

  • To investigate the factors influencing U.S. healthcare professionals' intentions to adopt biosimilars.
  • To analyze the role of the Theory of Planned Behavior (TPB) in predicting healthcare professionals' intentions towards biosimilars.

Main Methods:

  • A cross-sectional study surveyed 510 U.S. healthcare professionals (279 physicians, 231 pharmacists).
  • The Theory of Planned Behavior (TPB) constructs were assessed as predictors of biosimilar adoption intentions.
  • Statistical analyses included descriptive statistics, chi-square tests, and logistic regression modeling.

Main Results:

  • Physician intentions towards biosimilars were divided, with a majority being older males in the private sector.
  • Pharmacists, particularly females and community pharmacists, demonstrated higher intentions to use biosimilars.
  • Positive correlations were found between beliefs and intentions, with the exception of normative beliefs; years of practice also showed significant associations.

Conclusions:

  • Diverse attitudes toward biosimilars exist among U.S. healthcare professionals.
  • Targeted education on biosimilar manufacturing pathways is essential for physicians and pharmacists, especially those with less experience.
  • Enhanced education can promote appropriate biosimilar use and support the standardization of federal and state legislation.