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Expression and localization of HSD17B13 along mouse urinary tract
Haibo Zhang1, Jiazhen Chang1, Zhihong Dai2
1Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, People's Republic of China.
American Journal of Physiology. Renal Physiology
|May 23, 2024
Summary
17β-Hydroxysteroid dehydrogenase-13 (HSD17B13) is found in the mouse kidney, ureter, and bladder. This discovery provides a foundation for understanding HSD17B13
Area of Science:
- Nephrology
- Urology
- Hepatology
Background:
- 17β-Hydroxysteroid dehydrogenase-13 (HSD17B13) is a lipid droplet-associated protein vital in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
- NASH is an independent risk factor for chronic kidney disease (CKD), often involving renal lipid accumulation.
- The specific role of HSD17B13 in kidney lipid accumulation remains largely unknown.
Purpose of the Study:
- To investigate the expression and localization of HSD17B13 within the mouse urinary tract.
- To establish a foundation for exploring HSD17B13's role in renal and urological diseases.
Main Methods:
- Bioinformatic analysis
- Immunostaining techniques
- Examination of mouse urinary system
Main Results:
- HSD17B13 is constitutively expressed throughout the mouse kidney, ureter, and urinary bladder.
- This study provides the first detailed localization of HSD17B13 in the mouse urinary system.
Conclusions:
- HSD17B13 is present in the mouse kidney and urinary tract.
- These findings support further research into HSD17B13's involvement in the pathogenesis of kidney and urinary tract diseases.
