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Updated: Jun 25, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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Published on: January 25, 2017

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IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

Ivo Röwekamp1, Laura Maschirow1, Anne Rabes1

  • 1Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|May 23, 2024
PubMed
Summary

Interleukin-33 (IL-33) negatively regulates IL-22 production, enhancing resistance to Streptococcus pneumoniae lung infections. Genetic and environmental factors influencing gut microbiota impact pneumonia susceptibility.

Keywords:
IL-22IL-33Streptococcus pneumoniaemicrobiotapneumonia

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