Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Threshold responses in formaldehyde-sensitive subjects.

W P Jordan, W T Sherman, S E King

    Journal of the American Academy of Dermatology
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Connecting the food and agriculture sector to nutrition interventions for improved health outcomes.

    Food security·2022
    Same author

    Effects of Riparian Buffer Vegetation and Width: A 12-Year Longitudinal Study.

    Journal of environmental quality·2016
    Same author

    Breastfeeding promotion for infants in neonatal units: a systematic review.

    Child: care, health and development·2009
    Same author

    Breastfeeding promotion for infants in neonatal units: a systematic review and economic analysis.

    Health technology assessment (Winchester, England)·2009
    Same author

    Support for breastfeeding mothers.

    The Cochrane database of systematic reviews·2007
    Same author

    The effects of gap size and disturbance type on invasion of wet pine savanna by cogongrass, Imperata cylindrica (Poaceae).

    American journal of botany·2000
    Same journal

    Sexual function is missing from the adverse-effect map of GLP-1 receptor agonists in dermatology.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Comparative risk of reactivation of hepatitis B and C after treatment with biologics and targeted synthetic DMARDs in psoriasis and psoriatic arthritis: a 15-year multicenter cohort study.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Safety of Biologic Therapy in Psoriasis Patients With Malignancy.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Letter from the Editor: Glucagon-Like Peptide-1 (GLP-1) agonists in dermatology.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Rethinking the Occipital Scalp as a Control in Advanced Androgenetic Alopecia.

    Journal of the American Academy of Dermatology·2026
    Same journal

    Parallel-Polarized Dermoscopy for Acral Parallel Pattern Analysis.

    Journal of the American Academy of Dermatology·2026
    See all related articles

    Formaldehyde-sensitive individuals may tolerate low concentrations (30 parts per million) with repeated skin exposure. However, some preservatives release formaldehyde levels that could still trigger reactions in sensitive subjects.

    Area of Science:

    • Dermatology
    • Toxicology
    • Allergy Research

    Background:

    • Formaldehyde is a common allergen found in various consumer products.
    • Understanding safe exposure levels for formaldehyde-sensitive individuals is crucial for product formulation and consumer safety.

    Purpose of the Study:

    • To determine the threshold for formaldehyde-induced skin reactions in sensitive individuals under continuous and repeated exposure conditions.
    • To evaluate the potential for formaldehyde-releasing preservatives to elicit responses.

    Main Methods:

    • Continuous closed patch testing with low formaldehyde concentrations (30 parts per million - ppm) for up to 120 hours.
    • A double-blind, controlled, 2-week use test involving axillary application of a 30-ppm formaldehyde solution.

    Related Experiment Videos

    Main Results:

    • Continuous patch testing showed some formaldehyde-sensitive subjects reacted to 30 ppm formaldehyde after 120 hours.
    • Repeated axillary application of 30 ppm formaldehyde was generally tolerated, suggesting lower levels may be safe for normal skin.
    • Some formaldehyde-releasing preservatives may exceed this tolerance threshold.

    Conclusions:

    • A 30 ppm formaldehyde concentration may be a threshold for eliciting reactions in some sensitive individuals with prolonged contact.
    • Repeated, lower-level exposure to formaldehyde on normal skin appears to be better tolerated.
    • Careful consideration of formaldehyde-releasing preservative concentrations is necessary to avoid triggering reactions in sensitive populations.