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Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma
Miao Zhu1,2, Qing-Qing Shi2, Jun Ni2
1Department of Hematology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.
Chinese Journal of Integrative Medicine
|May 23, 2024
Summary
Celastrus orbiculatus extracts (COE) show anti-tumor effects by inducing lymphoma cell apoptosis and reducing inflammatory factors. COE also helps regulate thrombophilia associated with the tumor microenvironment, improving survival in mice.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Lymphoma proliferation is often associated with inflammation and thrombophilia.
- Celastrus orbiculatus extracts (COE) are being investigated for their potential therapeutic properties.
Purpose of the Study:
- To evaluate the anti-proliferative and immune-regulatory effects of COE on lymphoma cells.
- To assess the impact of COE on inflammation and thrombophilia in a lymphoma mouse model.
Main Methods:
- In vitro: 38B9 lymphoma cells treated with COE and CTX; apoptosis, cell cycle, and inflammatory factors (IL-6, IL-10, TNF-α) analyzed.
- In vivo: Lymphoma mouse model treated with COE and CTX; plasma inflammatory factors, thrombus indexes (D-dimer, vWF, TF), NETs, CLEC-2, tumor growth, and survival monitored.
Main Results:
- COE induced apoptosis and affected cell cycle phases in lymphoma cells.
- COE treatment reduced pro-inflammatory cytokines (IL-6, TNF-α) and increased anti-inflammatory cytokine (IL-10).
- In vivo, COE reduced tumor mass, prolonged survival, and modulated inflammatory and thrombotic markers, including NETs, TF, D-dimer, and CLEC-2.
Conclusions:
- COE exhibits a mild, stable anti-tumor effect against lymphoma.
- COE mitigates lymphoma-associated inflammation and regulates the tumor-induced thrombophilic state.
