Related Experiment Video
Updated: Jun 25, 2025
07:12
Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
Published on: January 19, 2020
9.3K
The relationship between SGLT2 and systemic blood pressure regulation
Priscilla Ahwin1, Diana Martinez2
1Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 South Broadway, Camden, NJ, 08103, USA.
Summary
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower blood pressure independently of glucose levels. This review explores SGLT2
Area of Science:
- Nephrology
- Cardiology
- Neuroscience
Background:
- Sodium-glucose cotransporter 2 (SGLT2) is primarily in the kidney, reabsorbing glucose.
- SGLT2 is also found in the central nervous system, influencing cardiorespiratory regulation.
- SGLT2 inhibitors are used for diabetes but show blood pressure-lowering effects.
Purpose of the Study:
- To review the function of SGLT2 and its inhibitors.
- To evaluate the role of SGLT2 in blood pressure control.
- To explore potential central nervous system mechanisms for SGLT2's antihypertensive effects.
Main Methods:
- Literature review of SGLT2 function and pharmacology.
- Analysis of studies on SGLT2 inhibitors and blood pressure.
- Exploration of SGLT2 expression in the central nervous system.
Main Results:
- SGLT2 inhibitors reduce blood pressure independent of glycemic control.
- SGLT2 is present in brain regions affecting blood pressure regulation.
- Evidence suggests a role for SGLT2 in central mechanisms of blood pressure management.
Conclusions:
- SGLT2 inhibitors may offer a novel therapeutic approach for hypertension.
- Further research is needed to elucidate SGLT2's central nervous system role in blood pressure.
- SGLT2 inhibitors could be future antihypertensive agents.
Related Concept Videos
01:27Glucose Transporters
22.7K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.7K
01:32Secondary Active Transport
7.0K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
7.0K
01:28Glomerular Filtration Rate and its Regulation
2.6K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.6K
01:26Glucose Absorption Into the Small Intestine
31.6K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.6K
01:18Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
01:33Hormonal Regulation
33.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.1K