Related Experiment Video
Updated: Jun 25, 2025

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
Published on: November 15, 2024
Campbell's Law Explains the Replication Crisis: Pre-Registration Badges Are History Repeating
1The University of British Columbia, Vancouver, Canada.
Campbell's Law suggests that treating scientific tools like pre-registration badges as goals distorts their use, potentially harming psychological science. True scientific robustness relies on replication, not mandates.
Area of Science:
- Psychological science
- Research methodology
- Scientific integrity
Background:
- The replication crisis in science highlights issues with research practices.
- Campbell's Law describes how performance indicators can be distorted when pursued as goals.
- Existing tools like p-values and hypotheses have been misused, contributing to fragile findings.
Purpose of the Study:
- To examine whether pre-registration mandates, such as pre-registration badges (PRBs), are an effective solution to the replication crisis.
- To argue that PRBs, like other tools, may be distorted and harm scientific progress.
- To propose alternative solutions for fostering robust science.
Main Methods:
- Conceptual analysis applying Campbell's Law to pre-registration mandates.
- Review of existing evidence on the use and misuse of pre-registration badges.
- Argumentation based on theoretical principles and observed trends in scientific practice.
Main Results:
- Pre-registration mandates, like PRBs, risk becoming goals in themselves, leading to distorted use.
- Evidence suggests that papers seeking PRBs may violate their spirit and rules.
- Pre-registration mandates may discourage optimal practice, worsen the file drawer problem, and encourage 'pre-registering after results are known' (PRARKing).
Conclusions:
- Pre-registration mandates may create a false sense of trust in unreliable findings.
- A combination of design features (sample size, measurement, robustness checks, pre-registration) supports replicability, but none should be canonized.
- The most crucial solution is a sociocultural shift towards valuing and reinforcing robust science over "flashy but fragile" science.
More Related Videos
07:55Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae
Published on: September 11, 2022
11:19Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System
Published on: August 21, 2016
Related Concept Videos
The Replisome
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
S-Cdk Initiates DNA Replication
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
Restarting Stalled Replication Forks
Social Proof
Chromosome Structure
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...