Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

27.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.9K
Pain01:20

Pain

474
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
474
Analgesia and Pain Management01:25

Analgesia and Pain Management

582
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
582
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

10.9K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does mesenchymal stem cell's secretome affect spinal sensory circuits? Implication for pain therapies.

Neural regeneration research·2024
Same author

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions.

International journal of molecular sciences·2024
Same author

Co-cultures of cerebellar slices from mice with different <i>reelin</i> genetic backgrounds as a model to study cortical lamination.

F1000Research·2023
Same author

Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death.

International journal of molecular sciences·2022
Same author

The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age.

Molecules (Basel, Switzerland)·2021
Same author

Association of Caspase 3 Activation and H2AX γ Phosphorylation in the Aging Brain: Studies on Untreated and Irradiated Mice.

Biomedicines·2021

Related Experiment Video

Updated: Jun 25, 2025

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.2K

Brain-Derived Neurotrophic Factor, Nociception, and Pain.

Adalberto Merighi1

  • 1Department of Veterinary Sciences, University of Turin, 10095 Turin, Italy.

Biomolecules
|May 24, 2024
PubMed
Summary

Brain-derived neurotrophic factor (BDNF) plays a key role in pain signaling. This review explores BDNF

Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for neuronal survival and plasticity.
  • BDNF is increasingly recognized for its role in modulating synaptic transmission.
  • Understanding BDNF's function in pain pathways is vital for developing new pain therapies.

Purpose of the Study:

  • To review the involvement of BDNF in the control of nociception and pain.
  • To elucidate the molecular mechanisms of BDNF in pain processing.
  • To discuss therapeutic strategies targeting BDNF for pain management.

Main Methods:

  • Comprehensive literature review of studies on BDNF and pain.
  • Analysis of molecular mechanisms underlying BDNF's role in nociception.
Keywords:
BDNFLTPglianeuronsneuropeptidesnociceptionpainpostsynaptic mechanismspresynaptic mechanisms

More Related Videos

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.2K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

2.4K

Related Experiment Videos

Last Updated: Jun 25, 2025

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.2K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.2K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

2.4K
  • Examination of preclinical and clinical research on BDNF-based pain therapies.

    • Main Results:

    • BDNF significantly influences both physiological and pathological pain states.
    • Molecular pathways involving BDNF in pain processing have been identified.
    • BDNF and its mimetics show promise as therapeutic agents for pain.

    Conclusions:

    • BDNF is a critical regulator of pain perception and processing.
    • Targeting BDNF pathways offers potential for novel pain management strategies.
    • Further research is needed to overcome challenges in clinical translation of BDNF therapies.