Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Antibiotic Selection00:57

Antibiotic Selection

53.2K
Overview
53.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes.

Toxins·2026
Same author

Anthrax Toxin: A Pioneer of Targeted Protein Toxins.

Toxins·2025
Same author

Injection of Affibodies by a Self-Organizing Bacterial Syringe to Interfere with Intracellular Signaling.

Toxins·2025
Same author

Antibodies Directed Against GalNAc- and GlcNAc-O-Tyrosine Posttranslational Modifications - a New Tool for Glycoproteomic Detection.

Chemistry (Weinheim an der Bergstrasse, Germany)·2023
Same author

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor.

PLoS pathogens·2022
Same author

CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo.

Toxins·2021

Related Experiment Video

Updated: Jun 25, 2025

Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy
14:29

Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy

Published on: October 1, 2012

12.0K

Some Examples of Bacterial Toxins as Tools.

Gudula Schmidt1

  • 1Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.

Toxins
|May 24, 2024
PubMed
Summary

Bacterial protein toxins, which enter host cells to modify proteins, are valuable tools in cell biology. Their enzymatic and transport functions are engineered for research, enabling studies of signaling pathways and intracellular delivery.

Keywords:
bacterial toxinprotein deliverytool

More Related Videos

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
09:25

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

Published on: August 19, 2016

11.0K
A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
14:10

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

8.6K

Related Experiment Videos

Last Updated: Jun 25, 2025

Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy
14:29

Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy

Published on: October 1, 2012

12.0K
Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
09:25

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

Published on: August 19, 2016

11.0K
A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
14:10

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

8.6K

Area of Science:

  • Microbiology
  • Cell Biology
  • Biochemistry

Background:

  • Pathogenic bacteria utilize protein toxins to breach host defenses and establish infections.
  • These toxins enter mammalian cells, catalyzing diverse protein modifications like ribosylation, deamidation, and adenylate cyclase activity.

Purpose of the Study:

  • To provide an overview of bacterial toxins as tools in cell biology.
  • To highlight the engineered applications of toxin enzymatic and transport functions in research.

Main Methods:

  • Review of existing literature on bacterial toxin mechanisms and applications.
  • Analysis of representative examples showcasing toxin-based research tools.

Main Results:

  • Bacterial toxins possess diverse enzymatic activities and cell-entry capabilities.
  • Engineered toxins serve as valuable tools for studying cellular signaling and delivering cargo into the cytosol.

Conclusions:

  • Understanding bacterial toxin molecular mechanisms has established them as powerful cell biology tools.
  • Both the enzymatic and pore-forming/transport capacities of toxins are exploited for scientific research.