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Published on: March 30, 2010

Early- and late-phase activation of complement evaluated by plasma levels of C3d,g and the terminal complement

T E Mollnes

    Complement (Basel, Switzerland)
    |January 1, 1985
    PubMed

    Insights

    Complement activation

    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • The complement cascade plays a crucial role in innate immunity.
    • Understanding complement activation phases is vital for clinical applications.

    Purpose of the Study:

    • To investigate the correlation between early and late complement cascade activation.
    • To compare the in vivo elimination rates of C3d,g and the fluid-phase terminal complement complex.

    Main Methods:

    • Quantification of C3d,g and fluid-phase terminal complement complex.
    • Analysis of spontaneous in vitro activation.
    • Analysis of in vivo activation during extracorporeal circulation in coronary artery surgery.

    Main Results:

    • A close but incomplete correlation was observed between early and late complement activation phases.
    • C3d,g and the terminal complement complex exhibit distinct in vivo elimination rates.
    • Both C3d,g and the terminal complement complex serve as valuable indicators for their respective activation phases.

    Conclusions:

    • Early and late complement activation are closely linked but not fully synchronous.
    • Distinct clearance kinetics of C3d,g and terminal complement complex impact their utility as biomarkers.
    • These markers offer valuable insights into complement system dynamics during surgical procedures.

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