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Related Experiment Video

Updated: Jun 25, 2025

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

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Understanding Mucosal Physiology and Rationale of Formulation Design for Improved Mucosal Immunity.

Mila Biswas¹, Md Nurunnabi^2,3, Zehedina Khatun²

¹Department of Electrical and Computer Engineering, University of Texas at El Paso, El Paso, Texas 79902, United States.

ACS Applied Bio Materials

|May 24, 2024

Summary

Mucosal membranes protect against pathogens. Advanced formulations like liposomes and mucoadhesive particles enhance mucosal immunity for better vaccine development.

Keywords:

infectious agents mucoadhesive polymer mucosal adjuvant mucosal drug delivery system mucosal immunity mucosal vaccine mucus layer

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Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

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Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

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Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

Area of Science:

Immunology
Biomaterials Science
Vaccinology

Background:

Mucosal membranes in the oral and nasal cavities are primary entry points for pathogens.
The mucosal barrier is essential for defense against infection and maintaining homeostasis.
Mucosal tolerance is vital for regulating physiological balance.

Purpose of the Study:

To review the role of material selection and delivery systems in optimizing mucosal immunity.
To highlight the potential of mucosal formulations in enhancing immune responses.

Main Methods:

Review of scientific literature on mucosal immunity and formulations.
Analysis of lipid-based (liposomes, virosomes) and polymeric delivery systems.
Evaluation of studies demonstrating immune response enhancement.

Main Results:

Lipid-based formulations (liposomes, virosomes) effectively induce local and systemic immunity.
Mucoadhesive polymeric particles provide prolonged delivery and enhanced immune responses.
Material choice and delivery strategy significantly impact mucosal immunity.

Conclusions:

Optimizing material selection and delivery approaches is key to enhancing mucosal immunity.
Mucosal vaccines utilizing advanced formulations show promise for improved immune stimulation.
Further research into mucosal delivery systems can lead to more effective vaccines.