Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Lethal Alleles

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Triglycerides play a crucial role in the pathway from depression to cardiomyopathy: A mediation Mendelian randomization study.

Medicine·2026

Same author

NG2 glia promote injured spinal cord repair through neuronal transdifferentiation and keratins expression in juvenile mice.

The spine journal : official journal of the North American Spine Society·2025

Same author

Analysis of the Autophagy-related Gene NLRC4 in spinal cord injury.

Neurological research·2025

Same author

Exosomal miR-151-3p in saliva: A potential non-invasive marker for gastric cancer diagnosis and prognosis modulated by Sijunzi decoction (SJZD) in mice.

Heliyon·2024

Same author

Elucidating the influence of familial interactions on geriatric depression: A comprehensive nationwide multi-center investigation leveraging machine learning.

Acta psychologica·2024

Same author

In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019.

Journal of ethnopharmacology·2021

Search research articles

Related Experiment Video

Updated: Jun 25, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Cholecystitis may decrease the risk of sudden death: A 2-sample Mendelian randomization study.

Shina Zhang¹, Boyang Sheng¹, Shuaishuai Xia¹

¹School of Traditional Chinese Medicine and School of Informatics are two departments of Hunan University of Chinese Medicine.

|May 24, 2024

Summary

Cholecystitis may reduce the risk of sudden cardiac death from ventricular arrhythmias and aortic aneurysms, according to a large-scale genetic study. This research clarifies the complex relationship between gallbladder inflammation and sudden death causes.

More Related Videos

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Related Experiment Videos

Last Updated: Jun 25, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Area of Science:

Cardiovascular Genetics
Gastroenterology
Epidemiology

Background:

Observational studies suggest a link between cholecystitis (gallbladder inflammation) and sudden death.
The precise causal relationship between cholecystitis and sudden cardiac death risk remains unclear.
Understanding this link is crucial for public health and clinical risk assessment.

Purpose of the Study:

To investigate the causal interplay between cholecystitis and the risk of sudden cardiac death.
To determine if cholecystitis influences the risk of specific sudden death etiologies.

Main Methods:

Utilized large-scale genome-wide association study (GWAS) summary data from UK Biobank, FinnGen, and European Bioinformatics Institute.
Employed two-sample Mendelian randomization (MR) analysis to assess causality.
Applied various MR methodologies (IVW, MR-Egger, weighted median) and performed heterogeneity, pleiotropy, and sensitivity analyses.

Main Results:

A statistically significant inverse correlation was found between cholecystitis and ventricular arrhythmias (OR=0.896, P=0.008).
An inverse association was also observed between cholecystitis and aortic aneurysm (OR=0.899, P<0.001).
No direct causal link was established between cholecystitis and cerebrovascular accidents, pulmonary embolism, or acute myocardial infarction.

Conclusions:

Cholecystitis appears to have a protective effect against sudden death specifically due to ventricular arrhythmias and aortic aneurysms.
The study suggests cholecystitis may mitigate the risk of these particular sudden death causes.
Findings provide novel insights into the complex relationship between gallbladder disease and cardiovascular outcomes.