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Microfluidic-Based dsRNA Delivery Nanoplatform for Efficient Spodoptera exigua Control.

Jinshan Xie1, Jiaxin Zhang1, Jingyi Yang1

  • 1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

Journal of Agricultural and Food Chemistry
|May 24, 2024
PubMed
Summary

A new microfluidic platform creates RNA interference (RNAi) nanopesticides continuously. This method ensures consistent quality for effective pest control by improving nanopesticide properties and delivery.

Keywords:
RNA interferenceSpodoptera exigualipid nanoparticlemicrofluidic technologynanopesticide

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Area of Science:

  • Nanotechnology
  • Agricultural Science
  • Molecular Biology

Background:

  • RNA interference (RNAi) offers potential for pest control.
  • Current RNAi nanopesticide production lacks consistent quality control due to batch processing.

Purpose of the Study:

  • To develop a microfluidic-based nanoplatform for continuous RNA nanopesticide preparation.
  • To improve quality control and efficiency in producing RNAi nanopesticides.

Main Methods:

  • Utilized microfluidic technology for continuous processing of RNA nanopesticides using lipid nanoparticles (LNPs).
  • Formed dsRNA-loaded LNPs (dsRNA@LNPs) rapidly with uniform size and enhanced properties.
  • Evaluated dsRNA@LNPs targeting the chitin synthetase B (CHSB) gene in *Spodoptera exigua*.

Main Results:

  • Microfluidic platform produced dsRNA@LNPs with uniform size, improved leaf wettability, and excellent dispersion.
  • dsRNA@LNPs demonstrated resistance to midgut fluid degradation.
  • dsCHSB@LNPs significantly increased pest mortality, reduced larval growth, and enhanced gene suppression.

Conclusions:

  • A continuous microfluidic nanoplatform enables high-quality RNAi nanopesticide production.
  • This technology accelerates the practical application of RNAi for pest control.
  • Microfluidics offers a scalable solution for consistent nanopesticide manufacturing.