Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time algorithm-driven ventilation feedback to improve lung-protective ventilation in patients with ARDS (REALVENT-study): study protocol for a multicentre randomised controlled trial.

Respiratory research·2026
Same author

Precision-guided immunomodulatory therapy in sepsis.

The Lancet. Respiratory medicine·2026
Same author

Impact of BMI on optimal PEEP titrated by electrical impedance tomography in ARDS patients: A retrospective study.

Respiratory medicine·2026
Same author

Interpreting wasted ventilation in EIT assessment of pulmonary embolism: ventilation-weighted high-V/Q burden versus perfusion-defect burden.

Critical care (London, England)·2026
Same author

Grading quality score of contrast electrical impedance tomography for lung ventilation-perfusion: development and preliminary evaluation of the impedance-time curve.

Respiratory medicine·2026
Same author

Electrical impedance tomography-derived flow index during spontaneous breathing trial stratifies the risk of reintubation within 48 h after extubation.

Critical care (London, England)·2026
Same journal

MCT1 inhibition reprograms Treg metabolism via ABC transporters: implications for tumor immunity and the prognosis of acute myeloid leukemia patients.

European journal of medical research·2026
Same journal

Delayed bedtime on workdays is associated with an increased prevalence of gallstones: a population-based study.

European journal of medical research·2026
Same journal

Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia-reperfusion injury via activation of the Nrf2 signaling pathway.

European journal of medical research·2026
Same journal

Clinical value of sputum galactomannan testing in the diagnosis of invasive pulmonary aspergillosis among chronic obstructive pulmonary disease patients.

European journal of medical research·2026
Same journal

Integrative analysis reveals luteolin's molecular targets and mechanisms in pancreatic cancer treatment.

European journal of medical research·2026
Same journal

Non-linear association between cardiometabolic index and helicobacter pylori infection: a cross-sectional study.

European journal of medical research·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.4K

SOFA in sepsis: with or without GCS.

Lu Wang1, Xudong Ma2, Guanghua Zhou3

  • 1Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, 100730, China.

European Journal of Medical Research
|May 24, 2024
PubMed
Summary
This summary is machine-generated.

Removing the Glasgow Coma Score (GCS) from the Sequential Organ Failure Assessment (SOFA) score improves prediction of ICU mortality in sepsis patients. This modification offers a more accurate assessment for severe sepsis cases.

Keywords:
Central nervous systemGCSRespiratorySOFASepsis

More Related Videos

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

7.6K
SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
11:05

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

14.7K

Related Experiment Videos

Last Updated: May 11, 2026

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.4K
Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

7.6K
SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
11:05

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

14.7K

Area of Science:

  • Critical Care Medicine
  • Sepsis Pathophysiology
  • Clinical Scoring Systems

Background:

  • Sepsis represents a significant global health challenge, necessitating accurate severity assessment tools.
  • The Sequential Organ Failure Assessment (SOFA) score is widely used for sepsis diagnosis and severity evaluation.
  • The Glasgow Coma Score (GCS), a component of SOFA, has reduced accuracy in intubated and sedated sepsis patients.

Purpose of the Study:

  • To evaluate the predictive performance of the SOFA score with and without the GCS for intensive care unit (ICU) mortality in sepsis patients.
  • To determine if omitting GCS enhances the accuracy of SOFA in predicting sepsis-related ICU mortality.

Main Methods:

  • A multicenter, cross-sectional study involving 3048 sepsis patients from Peking Union Medical College Hospital (PUMCH) and 18,108 patients from the eICU database.
  • Analysis focused on ICU mortality prediction using SOFA with and without GCS.
  • A subgroup of 2397 septic patients with SOFA respiratory score ≥ 3 from the eICU database was specifically analyzed for validation.

Main Results:

  • In the PUMCH cohort, SOFA without GCS demonstrated significantly higher predictive efficiency for ICU mortality across multiple time points (24h to 168h) compared to SOFA with GCS (AUROC values ranged from 0.724 to 0.781 vs. 0.708 to 0.770).
  • In the eICU subgroup (respiratory score ≥ 3), SOFA without GCS also showed a trend towards higher predictive efficiency for ICU mortality, although not statistically significant.
  • Statistical significance (P<0.05) was observed for the superiority of SOFA without GCS in the PUMCH data.

Conclusions:

  • Discontinuing the routine use of GCS in the SOFA score is feasible and realistic for severe sepsis patients, particularly those with a respiratory system score of 3 or higher.
  • Omitting GCS from the SOFA score can lead to improved prediction of ICU mortality in specific sepsis populations.
  • This finding supports refining sepsis assessment protocols by potentially removing GCS in certain clinical scenarios.